Issues

• Cyclicpeptide design

  NVIDIA-BioNeMo/Proteina-Complexa#58 · Filter by author Chunggggg opened on Jul 22, 2026

• The generated proteins from the motif scaffolding example are bad

  NVIDIA-BioNeMo/Proteina-Complexa#56 · Filter by author kgao86 opened on Jul 15, 2026
  2

• Cannot run on RTX 6000 / Blackwell (sm_120): pinned CUDA 12.6 + JAX 0.4.29 stack is incompatible

  NVIDIA-BioNeMo/Proteina-Complexa#54 · Filter by author sbonner0 opened on Jul 11, 2026

• which PLINDER release matches plinder_valid_ids.txt?

  NVIDIA-BioNeMo/Proteina-Complexa#52 · Filter by author mintuora opened on Jul 6, 2026

• Binder generation dies on FP64 torch.prod

  NVIDIA-BioNeMo/Proteina-Complexa#51 · Filter by author sbonner0 opened on Jul 5, 2026

• Question: Does changing target_hotspots affect binder generation?

  NVIDIA-BioNeMo/Proteina-Complexa#50 · Filter by author nikhilchil opened on Jun 29, 2026

• Non-standard amino acid

  NVIDIA-BioNeMo/Proteina-Complexa#49 · Filter by author augustus58978 opened on Jun 19, 2026

• [Proteina-Complexa] Setup docs overstate required credentials and mislabel DATA_PATH

  NVIDIA-BioNeMo/Proteina-Complexa#48 · Filter by author xinyu-dev opened on Jun 15, 2026

• [Proteina-Complexa] Skills lack a \"Limitations\" section (model scope is unstated)

  NVIDIA-BioNeMo/Proteina-Complexa#47 · Filter by author xinyu-dev opened on Jun 15, 2026

• [Proteina-Complexa] target_schema.md field documentation is inaccurate

  NVIDIA-BioNeMo/Proteina-Complexa#46 · Filter by author xinyu-dev opened on Jun 15, 2026

• [Proteina-Complexa] complexa validate target reports false failures for valid targets

  NVIDIA-BioNeMo/Proteina-Complexa#45 · Filter by author xinyu-dev opened on Jun 15, 2026

• [Proteina-Complexa] Local finetune crashes: SkipNanGrad incompatible with the fp16 GradScaler

  NVIDIA-BioNeMo/Proteina-Complexa#44 · Filter by author xinyu-dev opened on Jun 15, 2026

• [Proteina-Complexa] Sweep inf_* configs crash at evaluate (generate/evaluate path mismatch)

  NVIDIA-BioNeMo/Proteina-Complexa#43 · Filter by author xinyu-dev opened on Jun 15, 2026

• [Proteina-Complexa] Fresh UV env installs a torchaudio incompatible with torch → import crash

  NVIDIA-BioNeMo/Proteina-Complexa#42 · Filter by author xinyu-dev opened on Jun 15, 2026

• Missing complexa_cat.ckpt for fold class conditioned binder generation

  NVIDIA-BioNeMo/Proteina-Complexa#37 · Filter by author andrew-jia opened on May 13, 2026
  4

• RTX 5090 (sm_120) not supported - PyTorch cu126 incompatible with Blackwell architecture

  NVIDIA-BioNeMo/Proteina-Complexa#36 · Filter by author gabpellehuet opened on May 13, 2026
  1

• Question about motif + ligand scaffolding

  NVIDIA-BioNeMo/Proteina-Complexa#32 · Filter by author nicolasrincont opened on Apr 15, 2026
  4

• Question on GPU resources for training and inference

  question
  NVIDIA-BioNeMo/Proteina-Complexa#31 · Filter by author hyian113 opened on Apr 13, 2026

• Missing train configs/yamls

  NVIDIA-BioNeMo/Proteina-Complexa#30 · Filter by author Nik-BB opened on Apr 9, 2026

• Binder Redesign (as in Section 8)

  question
  NVIDIA-BioNeMo/Proteina-Complexa#26 · Filter by author SebiBorg opened on Apr 7, 2026

• Fork adapted to Mac users, now available

  enhancement
  NVIDIA-BioNeMo/Proteina-Complexa#24 · Filter by author fnachon opened on Apr 5, 2026

• Residue numbers of motif

  enhancement
  NVIDIA-BioNeMo/Proteina-Complexa#23 · Filter by author nicolasrincont opened on Apr 5, 2026
  1

• Masked target structure support

  question
  NVIDIA-BioNeMo/Proteina-Complexa#9 · Filter by author biochorl opened on Mar 19, 2026
  4

• Wet lab data availability

  question
  NVIDIA-BioNeMo/Proteina-Complexa#1 · Filter by author hypefolder opened on Mar 17, 2026
  1